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Literature summary extracted from

  • Chatterjee, K.; Guo, Z.; Vogler, E.; Siedlecki, C.
    Contributions of contact activation pathways of coagulation factor XII in plasma (2009), J. Biomed. Mater. Res. A, 90, 27-34.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.38 Kallikrein mediates activation of the zymogen FXII Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.38 additional information preparation of 3-aminopropyltriethoxysilane or n-octadecyltrichlorosilane particles as surfaces, i.e. procoagulants, for contact with the zymogen FXII, its kallikrein-mediated activation, and the activation of the human blood coagulation, surface cotact and assay method development and evaluation, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.38 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.38 prekallikrein + H2O Homo sapiens
-
 kallikrein + kallikrein prepeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.38 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.38 proteolytic modification kallikrein mediates activation of the zymogen FXII. Although autohydrolysis of FXII by FXIIa may be a significant reaction in neat protein solutions, it is insignificant in plasma, autohydrolysis also is a negligible contributor to FXII activation in material-induced plasma coagulation Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.38 blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.38 prekallikrein + H2O
-
 Homo sapiens kallikrein + kallikrein prepeptide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.38 coagulation factor XII
-
 Homo sapiens
3.4.21.38 FXII
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.38 physiological function kallikrein-mediated activation of the blood zymogen FXII dominates the activation of human blood plasma coagulation by contact with hydrophilic or hydrophobic surfaces, i.e. procoagulants, overview Homo sapiens